Two independent in vitro migration assays showed that the BAG 1 expressing MKN74 cells exhibited more active migration compared with control transfectants or parent MKN74 cells. In MKN74 cells, the overexpression of BAG 1 affected neither cell adhesion capability nor migration responses to HGF. The promotive effect of BAG 1 on cell migration was similarly observed in transfectants of another human gastric cancer MKN45 cell line.
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